Executive Director, Human Immunology Laboratory
The Executive Director, Human Immunology Laboratory (EDHIL) provides overall scientific and operational leadership of IAVI’s Human Immunology Laboratory (HIL) located at Imperial College London. This position is based in London and will report to the VP of Research Innovation and Integration (VP RII). The EDHIL is responsible for providing high-level strategic and tactical guidance to HIL staff with support from the Senior Director, HIL Global Operations and Scientific Director, HIL.
The EDHIL will provide scientific leadership and mentor-ship to the scientific and technical teams at the HIL and with partners globally. S/he will oversee the implementation of translational research and clinical development plans as it relates to assay development and validation to support the assessment of HIV vaccines as well as other vaccines in the IAVI portfolio, including Emerging Infectious Disease (EID) and TB vaccines. This will include developing and managing collaborations and partnerships worldwide and with other IAVI labs and sites.
The EDHIL will maintain a leadership position in immunology research communities, connecting IAVI scientists with collaborators around the globe. In particular the EDHIL will serve as an interface with key leaders at the Imperial College London, Department of Infectious Disease. They will expand and strengthen the long-standing partnership between IAVI and Imperial College London, to drive innovative joint research programs. The appointee may be offered an honorary academic appointment at a level appropriate to their scientific experience and caliber, to best facilitate this important partnership and identify synergies between the two institutions in areas of mutual interest.
The EDHIL will work closely with the VP RII to develop and integrate an overall HIL research strategy within the broader IAVI Strategy, contribute to portfolio review and prioritization, and will be part of the RII Leadership Team. The EDHIL will provide strategic advice regarding overall R&D efforts as required by participation on the IAVI R&D leadership team.
Finally, the EDHIL will lead the overall business planning for the HIL, identify what capabilities are needed within the HIL to execute on this plan, and contribute towards its implementation, including mentorship of personnel and their integration with other IAVI functional units. In accordance with the HIL business plan, the EDHIL will further establish the HIL as a center of excellence for IAVI in the areas of clinical assays, new assay development, global operations, and field site support. The EDHIL will build new and strengthen existing relationships with key thought leaders within European infectious disease consortia to identify areas of collaboration for translational research.
• Provide overall scientific and operational leadership of IAVI’s HIL by developing, executing and overseeing the strategic and scientific direction and planning for HIL and CRC laboratories
• Lead and mentor scientists experienced in a range of disciplines (including molecular and cell biology, immunology, genetics, and pharmacology) to develop deep mechanistic understanding of disease pathogenesis and confidence in target rationale
• Demonstrate and develop thought leadership in an area of immune disease research, publishing cutting edge science and developing and maintaining key collaborations around the globe
• Oversee a global operations capability that will enable clinical materials and data to be effectively and efficiently transported, stored, and accessed to support IAVI R&D objectives and selected collaborations
• Define role of HIL within overall IAVI European strategy in conjunction with IAVI’s Amsterdam office
• Manage HIL staff including scientists and operational staff from IAVI and Imperial College along with matrix reports based in Africa
• Manage collaborative relationships with project leads, key internal and external stakeholders, to resource and advance projects
• Represent IAVI’s human immunology laboratory internally and externally
• Recruit, retain and develop world-class scientific talent
• Serve in an academic role within Imperial College to expand the on-going collaboration and engage in lectures for the Imperial community
• Ensure that the projects directed are achieved at the highest level of scientific quality and the delivery of data is done in a timely manner
• Present information on results of these projects internally and externally as required
• Present the HIL and project teams persuasively to donors and potential donors as required
• Identify opportunities for obtaining Intellectual Property for IAVI
• Identify and apply for opportunities to obtain external funding for projects
EDUCATION AND WORK EXPERIENCE:
• PhD with 12+ years of R&D experience, deep expertise and outstanding record of research and recent publications in immunology
• 12 + years of experience in vaccine discovery and development preferred
• Knowledge of vaccine development from research through to manufacturing. Familiarity with clinical development and testing, Good Clinical Laboratory Practice (GCLP), method validation and the regulatory environment is desirable
• Demonstrated understanding of clinical assay development, qualification, and validation and its importance in clinical trial endpoint measurement
• Experience working in the developing world
• Expertise in extending discovery research through translational human biology to clinical development, using human biology approaches, biomarker development and validation, novel assay development and forward and back translation of research and clinical endpoints
• Demonstrated ability to effectively lead a team, work independently, and be an effective team member.
• Track record as a strong strategic thinker who can drive quickly to a clear and concise synthesis of complex issues and concepts and work towards novel solutions
• Proven ability and skills to present programs to scientific and non-scientific stakeholders
• Demonstrated ability to lead and influence others
OTHER KNOWLEDGE, SKILLS, AND ABILITIES:
• Excellent computer literacy skills with expertise in Microsoft Office (Word, PowerPoint, Outlook, SharePoint, Excel)
• Must maintain a professional demeanor, as well as a pleasant manner and positive “can-do” attitude while developing and maintaining communications in a cooperative and collaborative manner with all levels across teams both internally and externally
• Flexibility to change priorities and be comfortable with the changing deadlines to meet organization needs when required
• Strong interpersonal, leadership, and management skills
• Effective communication (both orally and in writing) and excellent listening skills; strong customer service orientation
• Commitment to IAVI’s mission and embodiment of IAVI’s core values
• Follows all company safety practices, Standard Operating Procedures (SOP’s) and policies
WORK ENVIRONMENT AND PHYSICAL DEMANDS:
The work environment and physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
• Mobility to perform the essential functions of the position
• Hearing and speech sufficient to verbally communicate in person and on the telephone constantly (66-100%)
Perform other duties as assigned
TRAVEL: up to 20% of time.
START DATE: As soon as possible
The International AIDS Vaccine Initiative (IAVI) is a nonprofit scientific organization whose mission is to translate scientific discoveries into affordable, accessible public health solutions to help the people who need them the most. Since its founding in 1996, IAVI has provided scientific, research and development, and policy leadership to address the needs of communities and key populations at risk for HIV infection around the world. IAVI works with more than 100 academic, industry, government, civil society, clinical, and community partners in more than 25 countries. IAVI is committed to supporting the broad field of HIV vaccine research and to fostering collaborations that accelerate the development and availability of new prevention tools. In pursuit of our goals, we work to catalyze and support novel partnership models that engage partners from both the public and private sectors across the product development continuum.
IAVI’s global reach, including its clinical research network in five countries in sub-Saharan Africa and in India, has allowed IAVI to make fundamental contributions to understanding of the epidemiology, transmission, natural history, virology, and immunology of HIV infection. This work played a key role in facilitating the structure-based design of promising HIV vaccine candidates as well as the discovery of “broadly neutralizing antibodies” that are now being advanced as promising approaches for HIV prevention. IAVI’s integrated capabilities in vaccine discovery, development, and clinical research take advantage of biopharmaceutical industry expertise to accelerate the development and testing of novel HIV vaccine candidates.
In addition to its core HIV vaccine effort, IAVI is working to amplify its global health impact by working with partners to address other urgent unmet public health needs – such as vaccines for other infectious diseases – where our existing technologies, assets, and experience can add unique value.
About the Human Immunology Lab
IAVI’s Human Immunology Laboratory (HIL) based at Imperial College London’s Chelsea and Westminster Hospital campus was founded in 2001 and funded primarily by IAVI. The HIL serves as the clinical immunology hub for the IAVI’s vaccine development partnerships. As an accredited Good Clinical Laboratory Practice (GCLP) laboratory with expertise in developing and conducting immunology assays for research and clinical trials, the HIL specializes in the analysis of immune responses as part of vaccine development partnerships. The HIL applies expertise toward the development of safe and effective vaccines against a range of diseases including HIV/AIDS, Lassa, Ebola, malaria, and tuberculosis. The HIL is also a central repository for clinical samples collected and received from clinical research centers worldwide, in support of IAVI clinical trials and epidemiology studies.
IAVI CORE VALUES
Dedication to the Mission: We are committed to the development of safe, effective, accessible, preventive HIV vaccines for use throughout the world to achieve a world without AIDS
Innovative Evolution: We are committed to solving complex problems in creative and innovative ways, learning from our mistakes and successes and never giving up
Integrity: We are committed to meeting the highest ethical and professional standards in everything we do and to taking responsibility for our actions to earn respect
Collaboration: We are committed to embracing diversity, the power of global teamwork and the belief that by working as one we can make a difference
Disclaimer: Nothing in this job description restricts management's right to assign or reassign duties and responsibilities to this job at any time. The above statements are intended to describe the general nature and level of work being performed by individuals assigned to this position. They are not intended to be an exhaustive list of all duties, responsibilities and skills required of personnel so classified. This document does not create an employment contract, implied or otherwise, other than an “at-will” relationship.
All IAVI employees are expected to follow and abide by the legal, financial, regulatory, safety, and other general guidelines of IAVI, and to conduct their activities in a manner consistent with the highest personal and professional standards.
IAVI is an equal opportunity employer and applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.